Filter

PURE SELECT® Cascade filter FractioPlas®19*

FILTER MEMBRANE MADE IN GERMANY

Our filters for plasma treatment contain membranes that are developed and produced in Germany for these special applications. The FractioPlas19* cascade filter was developed specifically for LDL apheresis. The dry filter selectively depletes the plasma components. There is only a reduced need or no need for substitution fluid. EO-free, gamma sterilisation.

FRACTIOPLAS®19* – USE OF THE PRODUCT

Therapeutic apheresis includes various types of extracorporeal removal of harmful substances or therapeutically active components from the blood or blood plasma.  Today, new methods of treatment based on blood filtration enable new therapies for a wide range of patients and indications. One example is LDL apheresis, which eliminates the low-density lipoprotein (LDL) cholesterol particle from the bloodstream in patients with familial hypercholesterolaemia. LDL cholesterol, which is referred to as "bad cholesterol," plays a role in the development of atherosclerosis.
It increases the risk of coronary disease, heart attack and even death. When conventional lipid-lowering treatment fails to reduce elevated LDL cholesterol to the desired level, LDL apheresis is a viable and effective option.

Benefits

Selective depletion of plasma components
No substitution fluid required
Easy to fill and handle
Dry filter
Low weight
EO-free

Details

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FractioPlas H 19

PURE SELECT® Cascade filter FractioPlas®10*

FILTER MEMBRANE MADE IN GERMANY

Our filters for plasma treatment contain membranes that are developed and produced in Germany for these special applications. The FractioPlas10* cascade filter was developed specifically for therapeutic apheresis. The dry filter selectively depletes the plasma components. There is only a reduced need or no need for substitution fluid. EO-free, gamma sterilisation.

FRACTIOPLAS®10* – USE OF THE PRODUCT

Following plasma separation, the plasma is taken through a second enhanced filter, which filters a wide variety of harmful substances from the plasma.The Pure SELECT® therapy series can be used in a wide range of therapeutic apheresis treatments.Examples include chronic diseases or autoimmune diseases, inflammation, damaged cells, deposited toxins and environmental influences.

Benefits

Selective depletion of plasma components
No substitution fluid required
Easy to fill and handle
Dry filter
Low weight
EO-free

Details

Pure Select® Kawasumi EVAFLUX*

FILTER MEMBRANE – EVAFLUXTM* SERIES

For double filtration plasmapheresis (DFPP) focusing on high molecular weight plasma components

  • Selective depletion of plasma components based on their molecular size
  • Reduced need or no need for substitution fluid
  • Wide range of applications
  • Indications (example):
    • Familial hypercholesterolaemia
    • ABO/HLA incompatible kidney transplantation
    • Autoimmune diseases

Details

Plasmafilter SepaPlas® 06

Filter membrane - Made in Germany

Our filters for plasma treatment contain membranes developed and produced in Germany for these special applications. The SepaPlas®06 plasma filter offers excellent biocompatibility and optimized separation of plasma and blood cells. It is perfectly suited for all plasma treatments. The hydrophilic membrane structure of the MicroPES® TF10 capillary membrane with its asymmetric pore structure provides a perfect balance between optimal cell separation and high plasma flow. EO-free, gamma sterilization.

SepaPlas® 06 - Use of the product

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Many factors, solely within the knowledge and control of the user, may affect the use and performance of a SepaPlas®06 in a particular application. Given the many factors that may affect the use and performance of this product, it is the sole responsibility of the user to evaluate this product and determine if it is suitable for a particular purpose and for the user's method of application.

Translated with www.DeepL.com/Translator (free version)

Benefits

Excellent biocompatibility
Optimized separation of plasma and blood cells
The ideal plasma filter for all plasma therapies
EO-free

Details

eine Tabelle der Kernkomponente für zahlreiche Plasmatherapien

Eine Makro aufnahme der Mikro PS

Ein Performance Graph von SepaPlas06

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Meise SepaPlas06

Pure Select® SERAPH®100* MICROBIND®* AFFINITY FILTER

SERAPH®100* Adsorber

A new option for the treatment of bloodstream infections

  • Innovative medical device for binding a broad spectrum of infectious pathogens.
  • Designed for safe and effective treatment of bloodstream infections, in combination with anti-infectives.
  • Enables > 99% reduction of pathogens in the bloodstream during a single treatment.
  • The adsorber can be used with standard equipment for renal replacement therapy.
  • It is possible to use the Seraph® independently of renal replacement therapy.

Seraph®100* is a unique tool, which offers a global solution for life-threatening blood infections

HOW IT WORKS - HEPARIN 2.0

  • The Seraph®100* weighing approx. 400 g contains polyethylene beads to which heparin is covalently bound.
  • The immobilised heparin is similar in structure to the glycocalyx on cell surfaces to which infectious pathogens also bind.
  • When blood flows through the adsorber, pathogens bind to the glycocalyx of cells due to the structural similarity of the heparin (biomimetics).
  • This irreversible binding resulting from biomimetics leads to a rapid and significant decrease (>99%) of pathogens present in the bloodstream.
  • The product is designed for low pressure drop operation at blood flow rates of up to 350 ml/min.

OVERVIEW OF PATHOGEN BINDING

MRSA E. faecium
S. aureus A. baumannii
K. pneumoniae S. epidermidis
K. pneumoniae (CRE) MRSE
K. pneumoniae (MDR) CMV
S. pyogenes Adenovirus
S. marcescens Zika
S. pneumoniae Ebola
E. faecalis C. albicans
E. faecalis (VRE) E. coli
E. coli (CRE)

Details

between cell surface with heparin/heparin sulphate and immobilised heparin on the surface of the seraph adsorption medium.

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Seraph 100 Microbind Affinity Filter

Pure Select® Plasmafilter Plasmacure PE*

PLASMA SEPARATOR FOR PLASMA EXCHANGE

  • Ethylene vinyl alcohol copolymer, a hydrophilic material, is coated on the surface of polyethylene hollow fibres
  • Gamma ray sterilised / ETO-free
  • Filtration characteristic is stable due to lower TMP increase

PLASMA SEPARATION USING MEMBRANE

Depending on their size, plasma components and blood cells are separated during plasma separation using a membrane plasma separator.

Details

Pure Select® Plasmafilter Versatile - PES*

PLASMA SEPARATOR FOR PLASMA EXCHANGE

VersatileTM-PES* is the new MEDICA hollow fibre membrane developed specially for plasma separation. It is a polyethersulfone membrane used for plasmapheresis and blood donation.

PLASMA SEPARATION USING MEMBRANE

An optimised diameter and wall thickness ensure a remarkable mechanical strength of the fibres and the largest filter area in the smallest space:

  • A very smooth inner membrane surface that ensures less damage to red blood cells in the bloodstream and minimises the risk of haemolysis.
  • A high separation performance in terms of plasma proteins passing through the membrane (over 90%)
  • An optimised membrane separation that allows a significant TMP value to be used.

Details

PURE SELECT® CASCADE FILTER FRACTIOSMART TM*

Cascade Filtration

FRACTIOsmart™* was developed to perform cascade filtration - a family of hollow fibre plasma fractionators made of polyethersulfone, versatile™ PES*.

FRACTIOsmart TM* - USE OF THE PRODUCT

Cascade filtration is a technique used in the treatment of various diseases to separate pathological molecules with a high molecular weight (such as immunoglobulin, cryoglobulins, LDL) from low molecular weight components that are physiologically useful (such as albumin, IgG, HDL). These components are then returned to the patient

Details

FRACTIOsmartTM* Small is indicated for IgD apheresis in the treatment of immunological diseases.

FRACTIOsmartTM* medium is indicated for immune complex and IgM apheresis.

FRACTIOsmartTM*Large is our suggested solution for LDL apheresis. LDL apheresis is a form of apheresis similar to dialysis to remove the low-density lipoprotein (LDL) cholesterol particles from the bloodstream. It is used in the case of diseases with high LDL, such as the rare homozygous familial hypercholesterolaemia, when the heterozygous form does not respond to drug treatment or if treatment has resulted in dangerous side effects (e.g., rhabdomyolysis).